Westmead will be added as a stop on the Bathurst Bullet train from late November.
Westmead will also be a stop on the new weekday Lithgow to Sydney CBD return express service, which was announced earlier in the year and is set to kick off late next month.
At the moment, the service stops at Lithgow, Mount Victoria, Katoomba, Springwood, Penrith and Parramatta before arriving at Central.
Member for Bathurst Paul Toole said the announcement was a boost for people needing fast access to the Westmead precinct.
The new Sydney to Lithgow morning express service will connect at Lithgow with regional coaches heading to Orange and Bathurst, while the return Lithgow to Sydney service will connect with coaches arriving from destinations such as Orange, Molong and Lucknow.